Clavospey


Prescription

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Amoxicillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many grampositive and gram-negative microorganisms. Amoxicillin is, however, susceptible to degradation by ß-lactamases. Clavulanic acid is a ß-lactam compound, structurally related to the penicillins, which possesses the ability to inactivate a wide range of ßlactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmidmediated ß-lactamases frequently responsible for transferred drug resistance.

Composition

Clavospey

Each film-coated tablet contains: amoxicillin 500 mg (as amoxicillin trihydrate BP), clavulanic acid 125 mg (as potassium clavulanate).

Clavospey

Each film-coated tablet contains: amoxicillin 875 mg (as amoxicillin trihydrate BP), clavulanic acid 125 mg (as potassium clavulanate).

Indications for use

For the treatment of urinary tract infection due to susceptible organisms; otitis media or sinusitis due to resistant microorganisms, e.g., H. Influenzae, S. Pneumoniae, M. Catarrhalis; lower respiratory tract and skin infections due to susceptible organisms; polymicrobial infections with mixed aerobic and anaerobic such as diabetic foot, gynecologic infections, intraabdominal infections.

Mode of application

Amoxicillin and potassium clavulanate combination may be taken without regard to meals; however, absorption of potassium clavulanate is enhanced when amoxicillin and potassium clavulanate combination is administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, the drug should be taken at the start of a meal. Duration of therapy should be appropriate to the indication and should not exceed 14 days without review.