Levocetirizine, the (R) enantiomer of cetirizine, is a potent and selective antagonist of peripheral H1 -receptors.
Levocetirizine inhibits eotaxin-induced eosinophil transendothelial migration through both dermal and lung cells. A pharmacodynamic showed three main inhibitory effects of levocetirizine 5 mg: inhibition of VCAM-1 release, modulation of vascular permeability and a decrease in eosinophil recruitment.
Each film-coated tablet contains: levocetirizine dihydrochloride 5 mg
Levocetirizine indicated in the symptomatic treatment of allergic rhinitis (including persistent allergic rhinitis) and urticaria in adults and children aged 6 years and above.
Oral Administration Swallowed whole tablet with liquid and may be taken with or without food. It is recommended to take the daily dose in one single intake.
Posology
Adults and adolescents 12 years and above: the daily recommended dose is 5 mg.
Elderly
For the time being, there is no data to suggest that the dose needs to be reduced in elderly patients provided that the renal function is normal. Adjustment of the dose is recommended in elderly patients with moderate to severe renal impairment.
Dose Adjustment for Renal and Hepatic Impairment:
No dose adjustment is needed in patients with solely hepatic impairment. In patients with hepatic impairment and renal impairment, adjustment of the dose is recomended.
Each film-coated tablet contains: levocetirizine dihydrochloride 5 mg
Levocetirizine indicated in the symptomatic treatment of allergic rhinitis (including persistent allergic rhinitis) and urticaria in adults and children aged 6 years and above.
Oral Administration Swallowed whole tablet with liquid and may be taken with or without food. It is recommended to take the daily dose in one single intake.
Posology
Adults and adolescents 12 years and above: the daily recommended dose is 5 mg.
Elderly
For the time being, there is no data to suggest that the dose needs to be reduced in elderly patients provided that the renal function is normal. Adjustment of the dose is recommended in elderly patients with moderate to severe renal impairment.
Dose Adjustment for Renal and Hepatic Impairment:
No dose adjustment is needed in patients with solely hepatic impairment. In patients with hepatic impairment and renal impairment, adjustment of the dose is recomended.