Download the package insert

Methylprednisolone is a synthetic glucocorticoid with a pronounced action. Corticosteroids pass through cell membranes via diffusion to form complexes with specific cytoplasmic receptors which penetrate into the cell nucleus, bind the DNA and stimulate the transcription of the cRNA and subsequent protein synthesis of various enzumes with different functions un the body.


Each tablet contains:

Methylprednisolone 4-16 mg.

Indications for use

The product is used as a substitution therapy in edocrine disorders, such as primary and secondary adrenal insufficiency, and congenital adrenal hyperplasia.

Mode of application

Mode of administration: Oral.


The amount of the initial dose may vary, depending on the type and severity of disease/condition and the response to the treatment performed. The treatment should continue at this dosage regimen to achieving the desired clinical response. Very high doses are required in multiple sclerosis (200mg/kg daily), brain oedema(200-1000 mg daily) and organ transplantation (up to 7mg/kg daily).


The dosage in children is determined by the physician`s evaluation and is based on the clinical response. The treatment should be performed by administering the minimal effective dose for the shortest period of time. If possible, the daily dose should be administered as a single dose, every other day.


The treatment in the elderly, especially the continuous one, should be carefully performed with regard to more serious complications resultant from the undesirable effects in this age group, particularly, osteoporosis, diabetes, hypertension, higher susceptibility to infections and skin atrophy, etc.